| Title | [Relationship between SNP rs10774671 on OAS-1 gene and spontaneous HBeAg seroconversion in chronic HBV infection] | | Author(s) | Chen LB, Peng XM, Cao H, Zhang YF, Xu QH, Gao ZL | | Institution | Department of Infectious Diseases, Third Affiliated Hospital of Sun Yet-sen University, Guangzhou 510630, China. | | Source | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2009 Feb; 23(1):35-7. | | Abstract | OBJECTIVE: To investigate the relationship between the SNP rs10774671 on OAS-1 gene and spontaneous HBeAg seroconversion in chronic HBV infection.
METHODS: Blood samples were collected from 58 HBeAg positive, 68 anti-HBe positive patients with chronic HBV infection, and 72 normal control cases without HBV infection. Chromosomal DNA was extracted and OAS-1 gene was amplified. SNP genotyping was performed with the competitively differentiated polymerase chain reaction and enzyme immunoassay.
RESULTS: In HBeAg positive group, frequencies of genotype GG plus GA and allele G were 31.0% and 16.4%. They were 48.5% and 29.4% in anti-HBe positive group, and 50.0% and 28.4% in normal control group respectively. Differences between HBeAg positive group and anti-HBe positive group or normal control group were statistically significant. But they weren't between anti-HBe positive group and normal control group.
CONCLUSION: Allele G on SNP rs10774671 of OAS-1 gene maybe benefits patients with chronic HBV infection to achieve spontaneous HBeAg seroconversion. Genotyping on this SNP may be predicting valuable for interferon therapy for chronic HBV infection. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19799013 |
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